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Abstract #3693

Examining fMRI time-series Multi-Scale Entropy as a Biomarker for Excitation/Inhibition Balance in the Brain

Kaundinya Gopinath1, Eric Maltbie2, Leonard Howell2, and Phillip Sun2

1Department of Radiology & Imaging Sciences, Emory University, Atlanta, GA, United States, 2Yerkes National Primate Center, Emory University, Atlanta, GA, United States

The maintenance of a dynamic balance between excitatory and inhibitory synapses in the neocortex is critical for brain function. Many psychiatric disorders are characterized by disturbance of E/I balance. In this study we examined the potential of the fMRI time-series complexity metric multi-scale entropy (MSE) to act as a biomarker for E/I balance, using a non-human primate (NHP) model. We disturbed the E/I balance with the sub-anesthetic ketamine, which induces disinhibition of projection neurons, especially in prefrontal cortex (PFC) during fMRI of conscious NHPs. Our results confirmed that fMRI MSE is a sensitive marker for E/I balance in the brain.

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