Abstract #3694

Tuning Neuromodulation Effects by Orientation Selective Deep Brain Stimulation in the Rat Medial Frontal Cortex

Lauri J Lehto¹, Pavel Filip^1,2, Hanne Laakso^1,3, Alejandra Sierra³, Julia Slopsema⁴, Matthew D Johnson⁴, Lynn E Eberly⁵, Walter C Low⁶, Olli Gröhn³, Heikki Tanila³, Silvia Mangia¹, and Shalom Michaeli¹

¹Center Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, United States, ²First Department of Neurology, Faculty of Medicine, Masaryk University and St. Anne’s Teaching Hospital, Brno, Czech Republic, ³A. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland, ⁴Department of Biomedical Engineering, University of Minnesota, Minneapolis, MN, United States, ⁵Division of Biostatistics, University of Minnesota, Minneapolis, MN, United States, ⁶Department of Neurosurgery, University of Minnesota, Minneapolis, MN, United States

With simultaneous fMRI and Deep Brain Stimulation (DBS), we demonstrate modulation of activity in rat amygdala by using axon Orientation Selective Stimulation (OSS) DBS in rat infralimbic cortex, a homologue brain region for treating depression in humans. Our results demonstrate orientation selectivity based on number of activated pixels especially in the amygdala, though qualitatively also other brain areas showed modulation based on stimulation angle. OSS may add a new level of optimization for treating major depression disorders.

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