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Abstract #3696

Reduced brain functional connectivity induced by generalized pain identified by mice Rs-fMRI

Md Taufiq Nasseef1, Emmanuel Darcq1, Waiya Ma1, Jai Puneet Singh1, Naoki Dozono2, Kevin Lancon3, Philippe Seguela3, Hiroshi Ueda2, and Brigitte L. Kieffer1

1Department of Psychiatry, Mcgill University, Montreal, QC, Canada, 2Department of Pharmacology and Therapeutic Innovation, Nagasaki University Institute of Biomedical Sciences Nagasaki, Nagasaki, Japan, 3Department Neurology & Neurosurgery, Mcgill University, Montreal, QC, Canada

Fibromyalgia (FM) is a disorder characterized by generalized pain. The acid saline-induced muscle (ASM) model is considered an acceptable animal model of FM with widespread chronic pain. Here, we investigated the impact of FM-like pain on neural communication, using the ASM model with non-invasive mouse resting state fMRI. We found that generalized pain reduces functional connectivity at the level of periaqueductal gray and retrosplenial cortex, two regions related to pain processing and FM. Moreover, we found a positive correlation between pain sensitivity measured by Von Frey test and the intensity of FC reduction at individual subject level.

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