Fibromyalgia (FM) is a disorder characterized by generalized pain. The acid saline-induced muscle (ASM) model is considered an acceptable animal model of FM with widespread chronic pain. Here, we investigated the impact of FM-like pain on neural communication, using the ASM model with non-invasive mouse resting state fMRI. We found that generalized pain reduces functional connectivity at the level of periaqueductal gray and retrosplenial cortex, two regions related to pain processing and FM. Moreover, we found a positive correlation between pain sensitivity measured by Von Frey test and the intensity of FC reduction at individual subject level.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords