Abstract #3702

The Effect of IC Number Selection in Group ICA for Rat Functional Connectivity

Tyng-Shiuan Hsieh^1,2, Chia-Feng Lu³, Bao-Yu Hsieh⁴, Cheng-Yu Chen^2,5,6,7, and Yu-Chieh Jill Kao^2,6,7

¹School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan, ²Translational Imaging Research Center, Taipei Medical University Hospital, Taipei, Taiwan, ³Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, Taipei, Taiwan, ⁴Department of Biomedical Imaging and Radiological Science, China Medical University, Taichung, Taiwan, ⁵Department of Medical Imaging, Taipei Medical University Hospital, Taipei, Taiwan, ⁶Department of Radiology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan, ⁷Neuroscience Research Center, Taipei Medical University, Taipei, Taiwan

Optimal IC number used in the ICA has been a kernel issue for functional MRI (fMRI) analysis. Nevertheless, limited consensus in IC number selection was proposed for rodent brains. This study aims to explore the effect of IC numbers in rsfMRI analysis in rats and further compare the difference using two echo-planar image (EPI) protocols with commonly used in-plane resolution (546 µm vs. 208 µm). We demonstrated the similar pattern of functional regions as IC number increases using both EPI protocol, suggesting the feasibility to perform routinely used EPI protocol for rsfMRI in rats.

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