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Abstract #3703

Network structure of the mouse brain connectome with voxel resolution

Ludovico Coletta1,2, Marco Pagani2, Boris Bernhardt3, and Alessandro Gozzi2

1Center for Mind/Brain Sciences, University of Trento, Rovereto, Italy, 2Functional Neuroimaging Laboratory, Center for Neuroscience and Cognitive Systems @ UniTn, Istituto Italiano di Tecnologia (IIT), Rovereto, Italy, 3Multimodal Imaging and Connectome Analysis Lab, Montreal Neurological Institute, McGill University, Montreal, QC, Canada

We provide a fine-grained description of the network structure and topology of the mouse connectome with voxel-resolution. We show that structural connectivity hubs can be spatially segregated into a dichotomic set of neural sink and neural source regions, and that functional and structural hubs show concordant neuro-anatomical topography. We finally demonstrate that the modular structure of the mouse connectome recapitulates large-scale fMRI networks of the mouse brain, including a default mode network core community, which is characterized by high structural resilience. Our results lay the foundation for topologically-driven targeted manipulations of the mouse connectome.

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