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Abstract #3705

Normal variations in brain oxygen extraction fraction (OEF) are partly attributed to differences in end-tidal CO2

Dengrong Jiang1, Zixuan Lin1, Peiying Liu2, Sandeepa Sur2, Cuimei Xu2, George Pottanat2, Kaisha Hazel2, Sevil Yasar3, Paul Rosenberg4, Marilyn Albert5, and Hanzhang Lu2

1Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 2Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 3Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 4Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 5Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, United States

Quantitative assessment of brain oxygen extraction fraction (OEF) is of substantial clinical significance in many brain diseases. However, a remaining issue associated with OEF is its considerable inter-subject variations within healthy population. Therefore, it is important to investigate the physiological underpinnings of OEF variations among normal subjects. The present work used two studies, a discovery study and a verification study, to examine the extent to which end-tidal CO2 (EtCO2) can explain inter-subject variations in OEF. It was found that, across subjects, OEF is inversely correlated with EtCO2, and EtCO2 alone can account for about 50% of variances in OEF.

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