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Abstract #3706

Whole-brain OEF quantification: a comparison study between QSM and dual-gas calibrated BOLD

Yuhan Ma1, Hongfu Sun2, Junghun Cho3,4, Erin L. Mazerolle2, Yi Wang3,4, and G. Bruce Pike1,2

1McConnell Brain Imaging Centre and Department of Biomedical Engineering, McGill University, Montreal, QC, Canada, 2Hotchkiss Brain Institute and Department of Radiology, University of Calgary, Calgary, AB, Canada, 3Department of Biomedical Engineering, Cornell University, Ithaca, NY, United States, 4Department of Radiology, Weill Cornell Medical College, New York, NY, United States

The microvascular QSM approach for quantifying baseline brain oxygen metabolism has great potential due to its simple set-up and high spatial resolution. In this study, we aim to investigate the feasibility of the high SNR microvascular QSM-OEF technique with a hypercapnia gas challenge and compare OEF and CMRO2 measured by QSM-OEF with those measured using the dual-gas calibrated BOLD technique (DGC-BOLD-OEF), a reference standard. Baseline OEF and CMRO2 measured by hypercapnia QSM-OEF were found within the expected normal range for healthy subjects. Statistically significant but relatively small differences (5% difference) of OEF and CMRO2 were found between QSM-OEF and DGC-BOLD-OEF techniques.

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