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Abstract #3709

The temporal stability of BOLD is improved by calibrating the cerebral vascular reactivity underpinned by the vascular probability within the group

Yi-Tien Li1,2, Jacky Tai-Yu Lu3, Ren-Horng Wang3, Pu-Yeh Wu1, Ying-Hua Chu1, and Fa-Hsuan Lin1,4,5

1Institute of Biomedical Engineering, National Taiwan University, Taipei, Taiwan, 2Department of Medical Imaging, Taipei Medical University - Shuang-Ho Hospital, New Taipei, Taiwan, 3Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei, Taiwan, 4Department of Neuroscience and Biomedical Engineering, Aalto University, Espoo, Finland, 5Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada

We hypothesize that the local venule vasculature underlies the BOLD signal latency and its variability. This hypothesis was tested by measuring the BOLD signal in the human primary visual cortex with a 10-Hz sampling rate during a visuomotor and a breath-holding (BH) task. A venule probability (VP) map was estimated by susceptibility-weighted images. We found that VP was significantly correlated to the relative BOLD latency and relative latency variability during the visuomotor task. These correlations disappeared after subtracting the latency in the BH task from the latency in the visuomotor task. These results support our hypothesis.

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