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Abstract #3710

The neurovascular response is attenuated by focused ultrasound-mediated disruption of the blood-brain barrier

Nick Todd1, Yongzhi Zhang1, Margaret Livingstone2, David Borsook3, and Nathan McDannold1

1Brigham and Women's Hospital, Boston, MA, United States, 2Harvard Medical School, Boston, MA, United States, 3Boston Children's Hospital, Boston, MA, United States

Focused ultrasound (FUS) disruption of the blood-brain barrier (BBB) is a promising technology for achieving targeted delivery of pharmacological agents into the brain. While the method has been shown to be safe from the standpoint of not damaging tissue cells, it causes other changes to local physiology that are not fully understood. This study aims to characterize the effects on the hemodynamic response that FUS BBB opening causes. We present BOLD and CBF fMRI results to investigate the particular mechanisms within the neurovascular response responsible for this effect.

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