Evidence of cell swelling upon activation has been observed in early diffusion functional MRI studies, and has been attributed to the co-transported water due to transient changes in ionic transmembrane flux. Blood-brain barrier (BBB) water permeability is also believed to be a marker of cerebral metabolism. Here we provide an initial investigation of visual stimulation on BBB water permeability parameters, water extraction fraction (Ew) and permeability surface area product (PSw), using the recently developed Intrinsic Diffusivity Encoding of Arterial Labeled Spins (IDEALS). Significant increase of PSw were observed with no change of Ew in the visual cortex during visual stimulation.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords