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Abstract #3712

Improved sensitivity for detecting functional CBF changes by center-out EPI with very short echo time

Ratnamanjuri Devi1, Toralf Mildner1, Kathrin Lorenz1, Jöran Lepsien1, and Harald E. Möller1

1Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany

Compared to BOLD imaging, the detection of functional CBF changes by arterial spin labeling is difficult due to the inherently small signal changes in the range of one percent or less. We compared a multi-echo EPI readout to center-out EPI that achieves a very short TE. The reduction of the minimum TE from 9.3 ms (multi-echo EPI) to a value of 1.8 ms (center-out EPI) yielded significantly improved statistical power in the human visual cortex in addition to diminished confounding BOLD and physiological noise contributions.

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