Abstract #3718

Elevated activation of a murine limbic network during cue-reward association learning revealed in 15.2 T fMRI

Keisuke Sakurai¹, Shota Ando¹, Chihiro Takahashi¹, Teppei Shintani¹, Wonbeom Jung², Dinh Thi Ngoc Anh², Chanhee Lee², Yunbok Kim², Seong-Gi Kim², and Tatsuhiro Hisatsune¹

¹Department of Integrated Biosciences, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan, ²Center for Neuroscience Imaging Research, Institute for Basic Science, Suwon, Korea, Republic of

An operant learning device for head-fixed mouse was developed for ultra-high field (15.2 Tesla) fMRI. Habituated mice were learned to water reward, associated with cue of light stimulation as a conditioning stimulus. We obtained 1,000 sets of BOLD fMRI (GE-EPI, TR/TE = 1000/11 ms), and found that elevated activation of a limbic learning network, including the entorhinal, perirhinal, and retrosprenial cortices and the hippocampal formation, during cue-reward association in learned mice.

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