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Abstract #3718

Elevated activation of a murine limbic network during cue-reward association learning revealed in 15.2 T fMRI

Keisuke Sakurai1, Shota Ando1, Chihiro Takahashi1, Teppei Shintani1, Wonbeom Jung2, Dinh Thi Ngoc Anh2, Chanhee Lee2, Yunbok Kim2, Seong-Gi Kim2, and Tatsuhiro Hisatsune1

1Department of Integrated Biosciences, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan, 2Center for Neuroscience Imaging Research, Institute for Basic Science, Suwon, Korea, Republic of

An operant learning device for head-fixed mouse was developed for ultra-high field (15.2 Tesla) fMRI. Habituated mice were learned to water reward, associated with cue of light stimulation as a conditioning stimulus. We obtained 1,000 sets of BOLD fMRI (GE-EPI, TR/TE = 1000/11 ms), and found that elevated activation of a limbic learning network, including the entorhinal, perirhinal, and retrosprenial cortices and the hippocampal formation, during cue-reward association in learned mice.

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