fMRI signal covariation with fluctuations in systemic physiology, including cardiac rate and respiration, is well established. Recent work showed strong correlations between peripheral vascular tone, a proxy for sympathetic activity, and fMRI global signal during drowsiness and sleep. As sympathetic activity may also be triggered by inspiration, even during the alert waking condition typical of task fMRI, we investigated the relationship between respiration, peripheral vascular tone, and fMRI signal during a visual task.
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