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Abstract #3725

VASO signal decreases associated with BOLD increases: a possible role of CSF volume redistribution

Marcello Venzi1, Joseph Whittaker1, Laurentius Huber2, and Kevin Murphy1

1School of Physics & Astronomy, Cardiff University, Cardiff, United Kingdom, 2NIMH, Bethesda, MD, United States

Using manipulations of the arterial tension of carbon dioxide, we demonstrate that the paradoxical decrease in CBV associated with BOLD increases is restricted to voxels with large proportions of CSF. Excluding those voxels , we show that visual responses during hypercapnia have no change in amplitude in VASO and BOLD contrasts, but the time-to-peak of BOLD responses lengthens and CBV peak times, being longer at baseline, remain the same.

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