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Abstract #3732

Distinct Patterns of Interhemispheric Connectivity in Patients with Early- and Late-Onset Alzheimer’s Disease

Kaicheng li1, Xiao Luo1, Qingze Zeng1, Peiyu Huang1, Yong Zhang2, and Min-Ming Zhang1

1The 2nd Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, China, 2GE Healthcare Shanghai, Shanghai, China

Early-onset Alzheimer’s disease (EOAD) presents a different clinical profile than late-onset Alzheimer’s disease (LOAD). We used voxel-mirrored homotopic connectivity (VMHC) to examine interhemispheric functional connectivity and tract-based spatial statistics (TBSS) to reflect the diffusion index. We found EOAD patients exhibited more widely disrupted interhemispheric functional and structural connectivity, which related to executive deficits. Our study suggested that different interhemispheric connectivity damage patterns may contribute to the distinctclinical profiles in EOAD and LOAD.

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