Early-onset Alzheimer’s disease (EOAD) presents a different clinical profile than late-onset Alzheimer’s disease (LOAD). We used voxel-mirrored homotopic connectivity (VMHC) to examine interhemispheric functional connectivity and tract-based spatial statistics (TBSS) to reflect the diffusion index. We found EOAD patients exhibited more widely disrupted interhemispheric functional and structural connectivity, which related to executive deficits. Our study suggested that different interhemispheric connectivity damage patterns may contribute to the distinctclinical profiles in EOAD and LOAD.
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