Abstract #3734

IVIM-based cerebral perfusion (in ml/100g/min) values at rest, hypercapnia and ischemia in an MCA occlusion model

Mira Liu¹, Yong Jeong², Niloufar Saadat¹, Gregory Christoforidis¹, and Timothy Carroll¹

¹Department of Radiology, University of Chicago, Chicago, IL, United States, ²Bioengineering and Biomedical Engineering, Northwestern, Chicago, IL, United States

This is a preliminary study of intravoxel incoherent motion (IVIM) in a two day study of normocapnia, hypercapnia, and post middle cerebral artery occlusion. It was established that IVIM perfusion values are linearly correlated to the reference perfusion values under a variety of physiologic states meaning IVIM perfusion values can be easily quantified. Once scaled, the IVIM CBF of white matter and grey matter normocapnia and post-occlusion cortex on both hemispheres were strongly correlated to the reference standard.

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