Blood oxygenation level dependent (BOLD) functional magnetic resonance imaging (fMRI) is widely used to assess local neuronal activity. However, the absolute metabolic demand related to BOLD-signal change is still largely unknown. In the current study we investigated the feasibility of multi-parametric quantitative BOLD (mq-BOLD) measurements to detect changes in tissue oxygenation in healthy, cortical gray matter during different states of visual stimulation. Our results show that mq-BOLD measurements are well feasible for standard activation paradigms. However, subject motion and transient states of brain activation might impact on quantitative parameter mapping due to longer acquisition times.