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Abstract #3736

Quantitative functional imaging of visual cortex activity in humans using multi-parametric blood oxygenation level dependent MRI

Christine Preibisch1,2,3, Stella Koutsouli1, Stephan Kaczmarz1,4, Samira Epp1, and Valentin Riedl1,2

1Neuroradiology, Technische Universität München, Munich, Germany, 2TUM-NIC, Technische Universität München, Munich, Germany, 3Clinic for Neurology, Technische Universität München, Munich, Germany, 4MRRC, Yale University, New Haven, CT, United States

Blood oxygenation level dependent (BOLD) functional magnetic resonance imaging (fMRI) is widely used to assess local neuronal activity. However, the absolute metabolic demand related to BOLD-signal change is still largely unknown. In the current study we investigated the feasibility of multi-parametric quantitative BOLD (mq-BOLD) measurements to detect changes in tissue oxygenation in healthy, cortical gray matter during different states of visual stimulation. Our results show that mq-BOLD measurements are well feasible for standard activation paradigms. However, subject motion and transient states of brain activation might impact on quantitative parameter mapping due to longer acquisition times.

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