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Abstract #3737

Dysfunction of functional connectivity between default mode network and cerebellar structures in patients with mTBI in acute stage. rsfMRI and DTI study.

Maxim Ublinskiy1,2, Natalia Semenova1,2, Tolib Akhadov1, Andrei Manzhurtsev2, Petr Menshchikov3, and Dmitriy Kupriyanov4

1Clinical and Research Institute of Emergency Pediatric Surgery and Trauma, Moscow, Russian Federation, 2Institute of Biochemical Physics Russian Academy of Sciences, Moscow, Russian Federation, 3Semenov institute of Chemical Physics of Russian Academy of Sciences, Moscow, Russian Federation, 4Philips Healthcare Russian Federation, Moscow, Russian Federation

The revealed changes in DMN neuronal connection and cerebellar regions in acute stage of mTBI patients can be an initial step of damages leading to cognitive deficit which can be developed in future in long-term period of injury. We suggest that further research in this direction will demonstrate whether DMN functional integrity analysis can serve as a biomarker for monitoring the recovery of patients with mTBI.

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