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Abstract #3743

The Relationship between Local Field Potential and Blood-oxygenation-level Dependent Signal Can Be Nonlinear

Xiaodi Zhang1, Wen-Ju Pan1, and Shella Keilholz1

1Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, United States

Many studies that involve simultaneous local field potential (LFP) and blood-oxygenation-level dependent (BOLD) signal measurements use correlation analysis, which assumes a linear relationship between the two. To experimentally determine whether the relationship is linear, we obtained a LFP vs BOLD response curve from simultaneous LFP and BOLD measurements. The relationship between the two was nonlinear under isoflurane but not under dexmedetomidine, which suggests that correlation may not always correctly capture the relationship between LFPs and BOLD.

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