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Abstract #3744

Divergent structural and functional changes across brain hierarchy account for population variation in demographics and behavior

Feng Han1 and Xiao Liu1,2

1Biomedical Engineering, Pennsylvania State University, State College, PA, United States, 2Institute for Cyber Science, Pennsylvania State University, State College, PA, United States

A robust link was recently established between resting-state functional connectivity and human behavioral measures. To understand the structural basis underlying this relationship, we examined the population covariation of the cortical thickness, resting-state connectivity, and a set of demographic and behavioral measures. We found that divergent changes at the lower- and higher-order brain regions in the cortical thickness and resting-state connectivity are structural and functional imaging features that are most tightly linked to the population behavioral variation. The findings suggest that differentiated changes across brain hierarchy could be important to brain function.

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