Abstract #3752

Optogenetically-evoked spindle-like activity from thalamus propagates brain-wide and enhances rsfMRI connectivity

Xunda Wang^1,2, Alex T. L. Leong^1,2, Shuai Guo^1,2, Celia M. Dong^1,2, and Ed X. Wu^1,2

¹Laboratory of Biomedical Imaging and Signal Processing, The University of Hong Kong, Hong Kong, China, ²Department of Electrical and Electronic Engineering, The University of Hong Kong, Hong Kong, China

Hierarchical nesting of spindles and slow oscillations have been identified as a unique characteristic for long-range functional neural integrations in thalamo-cortical network. Meanwhile, low spontaneous oscillatory neural activities are proposed to constrain and elicit resting state fMRI connectivity. Yet, the brain-wide spindle-related BOLD activity and the contribution of thalamic spindle-like activity to brain-wide rsfMRI connectivity remain largely unknown. We demonstrate for the first time that the spindle-like optogenetic stimulation at the somatosensory thalamus can evoke robust BOLD activations brain-wide and influence brain-wide rsfMRI connectivity. Our work suggests that interaction between spindles and slow oscillations is important for maintain rsfMRI connectivity.

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