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Abstract #3753

Towards artefact-free awake rat brain fMRI/EEG studies with multiband-SWIFT fMRI

Jaakko Paasonen1, Hanne Laakso1, Tiina Pirttimäki1, Petteri Stenroos1, Lauri Lehto2, Michael Garwood2, Shalom Michaeli2, Djaudat Idiyatullin2, Silvia Mangia2, and Olli Gröhn1

1A.I.V. Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland, 2Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, United States

EPI sequence is the most common choice for fMRI investigations. EPI, however, is loud for awake studies, prone to susceptibility-induced artefacts, and sensitive to motion. Therefore, we investigated whether the unique features of MB-SWIFT would make it a potential alternative for EPI to overcome these issues. Our results suggest that MB-SWIFT is dramatically more silent compared to EPI, body movement does not affect the voxels in brain, gradient-switching artefacts are minimal in electrophysiological data, and good quality resting-state fMRI data can be obtained from awake rats. We conclude that MB-SWIFT is an advantageous alternative to EPI in demanding experimental applications.

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