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Abstract #3755

Blocking AQP4 channels impacts BOLD fMRI but not Diffusion fMRI response patterns induced by visual stimulation

Yuji Komaki1, Clément Debacker1, Boucif Djemai1, Luisa Ciobanu1, Tomokazu Tsurugizawa1, and Denis Le Bihan1

1NeuroSpin, CEA, Saclay, France

We compared BOLD and Diffusion fMRI mouse brain maps obtained through visual stimulation before and after TGN-020 administration, an AQP4 receptor antagonist and astrocyte swelling inhibitor. Activations were observed in the primary visual cortex and the superior colliculus with both methods. BOLD signal changes were significantly increased after AQP4 inhibition, while the DfMRI signals were not affected. These results suggest that the DfMRI signal does not originate from astrocyte swelling.

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