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Abstract #3764

fMRI signal oscillations in rats can be induced by electric paw stimulation but do not deteriorate the observed BOLD peak

Henriette Lambers1, Lydia Wachsmuth1, Franziska Albers1, Martin Segeroth1, and Cornelius Faber1

1Translational Research Imaging Center (TRIC), University Hospital Muenster, Muenster, Germany

Signal time courses of BOLD fMRI measurements in rodents often show a damped oscillation which may superimpose with the expected hemodynamic response. In order to explore and characterize these oscillations, we performed EPI-BOLD measurements with high temporal resolution upon electrical paw stimulation. 55 % of the measurements showed oscillations with a frequency of 0.2 Hz. We could verify that these oscillations were induced by stimulation but did not affect the BOLD response. Consequently, hemodynamic response function models for statistical analysis are valid independently from the occurrence of oscillations.

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