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Abstract #3793

A combined task based fMRI connectivity and VBM study to lateralization of memory function in pre-and post-surgery mesial temporal lobe epilepsy patients.

Kapil Chaudhary1, Senthil Kumaran2, Sarat P Chandra3, and Manjari Tripathi1

1Neurology, AIIMS, New Delhi, India, 2NMR, AIIMS, New Delhi, India, 3Neurosurgery, AIIMS, New Delhi, India

Patients with temporal lobe epilepsy (TLE) have associated cognitive dysfunction and memory impairment on anterior temporal lobe resection (ATLR). Semantic verbal memory reorganization was investigated using functional connectivity (FC) and VBM in pre-and post-operative TLE subjects and healthy controls. Reduction in GM concentration was observed in left temporal lobe post-operatively in comparison to pre-surgery session and healthy controls. Semantic verbal memory components revealed increased FC in right hemisphere with decreased memory scores at follow-up (6 months post-surgery) compared to that of pre-surgery, indicating damage in the medial temporal region due to surgical resection resulting in semantic verbal memory network dysfunction.

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