Patients with temporal lobe epilepsy (TLE) have associated cognitive dysfunction and memory impairment on anterior temporal lobe resection (ATLR). Semantic verbal memory reorganization was investigated using functional connectivity (FC) and VBM in pre-and post-operative TLE subjects and healthy controls. Reduction in GM concentration was observed in left temporal lobe post-operatively in comparison to pre-surgery session and healthy controls. Semantic verbal memory components revealed increased FC in right hemisphere with decreased memory scores at follow-up (6 months post-surgery) compared to that of pre-surgery, indicating damage in the medial temporal region due to surgical resection resulting in semantic verbal memory network dysfunction.
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