Meeting Banner
Abstract #3794

Working memory deficits in childhood cancer survivors: an fMRI study

Patricia Stefancin1, Christine Cahaney1, Robert Parker2, Thomas Preston1, Laura Hogan2, Rina Meyer2, Cara Giannillo1, Debra Giugliano1, and Tim Duong1

1Stony Brook Medicine, Stony Brook, NY, United States, 2Stony Brook Children's Hospital, Stony Brook, NY, United States

Little is known about the neural correlates of cognitive deficits in chemotherapy treated survivors of childhood cancer. We used event related fMRI to study working memory in childhood cancer survivors. Subjects underwent an n-back task to test working memory function. Patients showed reduced BOLD signal on correct responses compared to controls in the anterior cingulate, posterior cingulate, and sensory association cortices. Patients showed increased activation on error trials in the angular gyrus and superior parietal lobule. The affected brain regions are known to be involved in memory function, reward, motor planning and motivation.

This abstract and the presentation materials are available to members only; a login is required.

Join Here