In order to explore the neural substrates underlying verbal memory (VM) impairment in subcortical stroke patients, we recruited sixty patients with chronic subcortical stroke and sixty normal controls. 3D-ASL imaging was used to measure the resting-state values of voxel-wise cerebral blood flow (CBF) and the alterations of functional covariance network were detected. In this study, the different CBF levels in the stroke patients and the normal controls, as well as the close correlation between the CBF values and the VM scores, indicate that the VM impairment in stroke patients may be associated with the disconnection of frontal-lobe network.
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