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Abstract #3800

Graph theoretic analysis of language sub-networks in Arabic-English bilingual patients undergoing fMRI for pre-surgical planning

Shruti Agarwal1, Mona Mohamed1, Hanzhang Lu1,2, and Jay J Pillai1

1Johns Hopkins University School of Medicine, Baltimore, MD, United States, 2Kennedy Krieger Institute, Baltimore, MD, United States

Task fMRI is routinely performed on patients for pre-surgical planning to localize critical components of the language network and assess hemispheric language dominance. However, the cortical representation of language in bilingual patients (those who are fluent in more than one language) is more complex than in monolinguals, and may involve overlapping but distinct sub-networks. The focus of our current study is to assess the functional connectivity strength of language networks derived from task fMRI activation maps obtained using paradigms performed in both primary native (L1) and secondary (L2) languages in a group of Arabic-English bilingual patients.

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