Abstract #3799

Abnormalities of intrinsic regional brain activity at resting state in schizophrenia: a meta-analysis of resting-state functional MRI

JiaYing Gong^1,2, Junjing Wang³, Xiaomei Luo¹, Guanmao Chen¹, Huiyuan Huang⁴, Ruiwang Huang⁴, Li Huang¹, and Ying Wang¹

¹Medical Imaging Center, First Affiliated Hospital of Jinan University, Guangzhou, China, ²Department of Radiology, Six Affiliated Hospital of Sun Yat-sen University, Guangzhou, China, ³Department of Applied Psychology, Guangdong University of Foreign Studies, Guangzhou, China, ⁴School of Psychology, Institute of Brain Research and Rehabilitation (IBRR), Center for the Study of Applied Psychology & MRI Center, Key Laboratory of Mental Health and Cognitive Science of Guangdong Province, South China Normal University, Guangzhou, China

Evidences of abnormal intrinsic brain activity in schizophrenia (SZ) are inconsistent demonstrated by previous studies. A meta-analysis that explored the differences of the ALFF between SZ patients (including first episode [FE] and chronic patients) and healthy controls were conducted. FE patients demonstrated decreased ALFF in the DMN and increased in the putamen, VN (visual network). Chronic patients showed decreased ALFF in the DMN, sensorimotor network, and VN and increased in the salience network, frontotemporal regions. Aberrant regional brain activity during the initial stage and widespread damage with the progression of disease contributes to understand the progressive pathophysiology feature of SZ.

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