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Abstract #3798

Abnormal local spontaneous brain activity revealed by resting-state fMRI as a biomarker for predicting radiation-induced neurocognitive dysfunction in patients with nasopharyngeal carcinoma

Yadi Yang1, Chuanmiao Xie1, Long Qian2, Zhipeng Li1, Yingwei Qiu3, and Xiaofei Lv1

1Department of Medical Imaging, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Guangzhou, China, 2GE Healthcare, MR Research China, Beijing, China, 3Department of Radiology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China

In this study, we hypothesize that radiation therapy induce longitudinal neurocognitive dysfunction in patients with nasopharyngeal carcinoma. To verify this hypothesis, resting-state functional magnetic resonance imaging (fMRI) was used to detect the local spontaneous brain activity in 38 patients with nasopharyngeal carcinoma 20 healthy controls at the baseline and follow-up examinations. The changes in brain activity at the early delayed stage after radiation therapy are then used to predict the brain functional impairment at a later stage. The results showed that radiation therapy may induce significant changes in reginal homogeneity in the brain, and such changes at early delayed stage may serve as a potential biomarker for predicting neurocognitive dysfunction at a later stage.

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