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Abstract #3812

Detecting T1-based Signal Reduction in Focused Ultrasound Heating of Bone using a 3D Spiral Ultra-Short Echo Time Sequence

Yekaterina K Gilbo1, Helen Sporkin1, Sam W Fielden2, John P Mugler3, Grady W Miller3, Steven P Allen1, and Craig H Meyer1

1Biomedical Engineering, University of Virginia, Charlottesville, VA, United States, 2Autism and Developmental Medicine Institute, Geisinger Health System, Danville, PA, United States, 3Radiology and Medical Imaging, University of Virginia, Charlottesville, VA, United States

MR-guided Focused Ultrasound (MRgFUS) is used transcranially to ablate brain tissue for the treatment of neurological diseases. Temperature monitoring of the skull is desired for increasing treatment safety and efficacy. Proton resonance frequency shift MR fails to detect heating in the cortical bone of the skull. T1-based MR thermometry uses T1 mapping to observe a linear increase in T1 with temperature but requires long acquisitions. We demonstrate a new thermometry method dependent on the linear relationship between signal magnitude from a T1-weighted 3D Spiral Ultra-short Echo Time sequence and test it across three scanners in multiple trials.

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