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Abstract #3813

Assessing the effect of pre-focal fat on the feasibility of delivering MR guided high intensity focused ultrasound (MRgHIFU) treatment of intra-pelvic tumors

Sharon L Giles1, Ian Rivens2, Gail R ter Haar2, and Nandita M deSouza1

1CRUK Cancer Imaging Centre, The Institute of Cancer Research and Royal Marsden Hospital, London, United Kingdom, 2Therapeutic Ultrasound, The Institute of Cancer Research, London, United Kingdom

Models were used to simulate the pre-focal tissue distributions encountered when treating intra-pelvic tumors with magnetic resonance guided high intensity focused ultrasound (MRgHIFU). Focal peak temperature and thermal dose volumes were considerably affected by depth and fat thickness. Exposures of 300 W for ≥20 s (≥6 kJ) were required to generate measurable 30EM dose contours 8 cm deep (6 cm pre-focal fat). The relative distributions of fat and muscle layers had minimal effect on focal heating, but influenced location of potentially damaging pre-focal heating. MRgHIFU treatments to deep-seated intra-pelvic tumors require methods for improving dose delivery at depth.

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