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Abstract #3814

Registration of In Vivo MR images to Volumetric Histopathology

Blake Zimmerman1, Sara Johnson1, Jill Shea2, Henrik Odeen3, Elaine Hillas2, Candace Winterton3, Robb Merrill3, Sarang Joshi1, and Allison Payne3

1Biomedical Engineering, University of Utah, Salt Lake City, UT, United States, 2Department of Surgery, University of Utah, Salt Lake City, UT, United States, 3Department of Radiology and Imaging Sciences, University of Utah, Salt Lake City, UT, United States

As MR guided focused ultrasound (MRgFUS) treatments evolve to treat oncological diseases, the ability to accurately assess the efficacy of treatment is critical. Although there are several MR metrics proposed for assessing MRgFUS treatments, they have not been rigorously validated against gold standard histopathology treatment assessment. Current validation studies that register MR to histopathology do not comprehensively account for all deformations during histological processing. We present a rigorous MR to histopathology registration pipeline that estimates deformation at every step that can be used to accurately validate the efficacy of oncological MRgFUS treatment.

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