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Abstract #3828

Power Considerations for Radiofrequency Applicator Concepts for Thermal Magnetic Resonance Interventions in the Brain at 297 MHz

Eva Oberacker1, Andre Kuehne2, Celal Oezerdem1, Jason M Millward1, Cecilia Diesch1, Thomas Wilhelm Eigentler1, Jacek Nadobny3, Sebastian Zschaeck3, Pirus Ghadjar3, Peter Wust3, Lukas Winter4, and Thoralf Niendorf1,2,5

1Berlin Ultrahigh Field Facility (B.U.F.F.), Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany, 2MRI.TOOLS GmbH, Berlin, Germany, 3Clinic for Radiation Oncology, Charite University Medicine, Berlin, Germany, 4Biomedizinische Magnetresonanz, Physikalisch Technische Bundesanstalt, Berlin, Germany, 5Experimental and Clinical Research Center (ECRC), joint cooperation between the Charité Medical Faculty and the Max Delbrueck Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany

There is a pressing need to implement Thermal MR therapies in the brain, particularly to sensitize treatment of aggressive cancers like glioblastoma multiforme. Given the high power transmission regime of Thermal MR therapies, it is crucial to understand the engineering constraints affecting RF power losses, since inaccurate estimates could compromise the efficiency and precision of the therapy. Here we conducted a thorough simulation of five RF applicator designs, using realistic loss estimates of material and electrical components, and considering antenna design, position and coupling. Results from simulated and patient-derived data underscore that clinical requirements must balance with practical engineering constraints.

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