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Abstract #3829

Flip angle optimization and in vitro demonstration of 2D DESPOT1-based fat thermometry

Beatrice Lena1, Clemens Bos1, Chrit T.W. Moonen1, Max A. Viergever1, and Lambertus W. Bartels1

1University Medical Center Utrecht, Utrecht, Netherlands

During MR-HIFU ablations, fat MR thermometry (MRT) is needed for monitoring temperature in adipose tissues (both in target regions and in subcutaneous fat in the near field of the ultrasound beam). It can be based on T1 mapping calculated with 2D-DESPOT1 method and corrected for the FA variation over the slice profile. However, difficulties arise in the choice of 2 flip angles optimized for the whole expected range of T1s in fat MRT. We identify the optimal settings through simulation and demonstrate the feasibility of fat MR thermometry through 2D DESPOT1 sequences in phantom experiments.

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