Meeting Banner
Abstract #3860

Multi-Slice LINE-scanning (MS-LINE) method to characterize the laminar specificity and variability in both evoked and resting-state fMRI

Sangcheon Choi1,2, Hang Zeng1,2, Bharat Biswal3, Bruce R. Rosen4, and Xin Yu1,4

1Max Planck Institute for Biological Cybernetics, Tuebingen, Germany, 2Graduate Training Centre of Neuroscience, Tuebingen, Germany, 3Department of Biomedical Engineering, NIJT, Newark, NJ, United States, 4MGH/MIT/HMS Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Harvard Medical School, Massachusetts General Hospital, Charlestown, MA, United States

Ultra-high field magnetic field strengths open new possibility for studying the neuronal input/output circuitry of the cortex and functional connectivity across the cortical layers. However, the spatiotemporal characteristics of laminar-specific fMRI signal remains to be better characterized in both task-related and resting state condition. Here, we present Multi-Slice FLASH based LINE-scanning (MS-LINE) methods, showing the multi-slice laminar-specific fMRI variability at different cortical regions of anesthetized rats. The results identify the distinct neurovascular coupling laminar patterns corresponding to different state of brain activity.

This abstract and the presentation materials are available to members only; a login is required.

Join Here