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Abstract #3861

Classification of sleep stages from fMRI dynamic functional connectivity using deep learning

Joana Carmona1, Rodolfo Abreu1, Carlos Santiago2, Alberto Leal3, Jacinto C. Nascimento2, and Patrícia Figueiredo1

1ISR-Lisboa/LARSyS and Department of Bioengineering, Instituto Superior Técnico - Universidade de Lisboa, Lisbon, Portugal, 2ISR-Lisboa/LARSyS and Department of Electrical Engineering, Instituto Superior Técnico - Universidade de Lisboa, Lisbon, Portugal, 3Department of Neurophysiology, Centro Hospitalar Psiquiátrico de Lisboa, Lisbon, Portugal

Sleep stage classifiers monitoring the wakefulness level of resting-state fMRI recordings have been proposed by several studies; however, the application of deep learning methods remains largely unexplored. We investigated the performance of Convolutional Neural Networks (CNNs) in the classification of sleep stages using fMRI-derived dynamic Functional Connectivity (dFC) features and simultaneous EEG-based labels. All tested architectures exhibited accuracies above 80%, with the best performance achieved using a shallow network. The learned filter weights were coherent with known stage-specific patterns of thalamo-cortical dFC. CNNs yielded comparable classification accuracy to Support Vector Machines (SVMs), without the need for exhaustive hyperparameter tuning.

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