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Abstract #3863

Altered Effective Connectivity Anchored in the Posterior Cingulate Cortex and the Medial Prefrontal Cortex in Cognitively Intact Elderly APOE ε4 Carriers: A Preliminary Study

Xiao Luo1, Kaicheng Li1, Qingze Zeng1, Peiyu Huang1, Yong Zhang2, and Minming Zhang1

1The 2nd Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China, 2GE Healthcare Shanghai, Shanghai, China

The APOE ε4 allele is the most reliable genetic risk factor for developing sporadic AD. Based on Granger causality analysis (GCA), we analyzed the APOE ε4-related effects on whole-brain directional connectivity in healthy elderly populations, by setting connected node located in anterior and posterior default mode network (DMN). We found that APOE ε4 carriers had reduced effective connectivity (EC) from the PCC to the anterior and posterior DMN subsystems; additionally, the carriers had increased EC from the parietal cortex to the anterior DMN subsystem. Second, the correlation analyses indicated the decreased EC in the carriers might result from neurofibrillary changes.

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