Abstract #3864

Olfaction connectivity in Patients with Parkinson’s disease: A comparative fMRI study.

S Senthil Kumaran¹, Shefali Chaudhary¹, Vinay Goyal², Priyanka Bhat², Ankita Sharma², Gauri Shanker Kaloiya³, and Mani Kalaivani⁴

¹NMR & MRI Facilty, All India Institute of Medical Sciences, New Delhi, India, ²Neurology, All India Institute of Medical Sciences, New Delhi, India, ³All India Institute of Medical Sciences, New Delhi, India, ⁴Biostatistics, All India Institute of Medical Sciences, New Delhi, India

Olfactory loss is one of the most common non-motor symptoms in Patients with Parkinson’s disease. ROI based functional connectivity analysis was performed on 10 healthy subjects (HC, 6M/4F, mean age=57±4.5 years) and 10 subjects with Parkinson’s disease (9M/1F, mean age=57.7±5.6 years) with olfaction fMRI (floral smell). Altered olfaction linked functional connectivity was present for amygdala, insula and cingulate gyrus in PD. Functional connectivity for olfactory cognition (hippocampus/orbitofrontal) was found intact in both the groups. Primary olfactory structures are more affected compared to the upstream structures, leading to the observed olfactory impairment.

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