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Abstract #3924

Relative assessment of language lateralisation with fMRI: evaluation of a novel threshold-independent method

Irène Brumer1,2, Enrico De Vita1, Jonathan Ashmore2,3, Jozef Jarosz2, and Marco Borri2

1Department of Biomedical Engineering, School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom, 2Department of Neuroradiology, King's College Hospital, London, United Kingdom, 3Department of Medical Physics and Bioengineering, NHS Highland, Inverness, United Kingdom

The assessment of language lateralisation with fMRI using the laterality index is limited by the dependence of the results on the chosen activation threshold. To overcome this limitation, different threshold-independent laterality index calculations have been introduced. This work proposes a new method and evaluates how it performs in comparison with three previously reported methods. The methods were evaluated on fifteen healthy subjects who performed picture naming, verb generation, and word fluency tasks. The novel method is simple to implement, fast, robust, reproducible, and compares well with the others in differentiating strong from weak lateralisation on both hemispheric and regional scales.

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