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Abstract #3932

Improving the sensitivity of Spin-Echo fMRI at 3.0 T by highly accelerated acquisitions

Antonia Barghoorn1, Bruno Riemenschneider1, Fei Wang1, Juergen Hennig1, and Pierre LeVan1

1Dept. of Radiology, Medical Physics, University Medical Center Freiburg, Freiburg, Germany

Spin-echo fMRI can be highly advantageous compared to gradient-echo fMRI with respect to magnetic field inhomogeneity artefacts, but is seldomly used for BOLD imaging due to its inferior sensitivity. The presented spin-echo implementation of a highly accelerated gradient-echo fMRI pulse sequence therefore aims to improve the sensitivity of spin-echo fMRI while profiting from a reduction of inhomogeneity-induced artefacts. Preliminary measurements using a temporal resolution of 134 ms for whole brain imaging show less signal dropout when compared to the gradient-echo counterpart, as well as an increase in the number of significantly activated voxels compared to the unaccelerated readout.

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