Abstract #3938

Olfactory functional MRI (fMRI) using T2-prepared BOLD fMRI at ultra-high field (7T)

Adrian G Paez^1,2, Suraj Rajan³, Grace-Anna Chaney⁴, Xinyuan Miao^1,2, Di Cao^1,2,5, Chunming Gu^1,2,5, Dapeng G Liu^1,2, Alex Y Pantelyat³, Liana I Rosenthal³, Zoltan K Mari⁶, Kelly Mills³, Ted M Dawson³, Peter C. M. van Zijl^1,2, Susan S Bassett⁴, David M Yousem⁷, Vidyulata Kamath⁴, and Jun G Hua^1,2

¹F.M. Kirby Research Center, Kennedy Krieger Institute, Baltimore, MD, United States, ²Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ³Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ⁴Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ⁵Biomedical Engineering, Johns Hopkins University, Baltimore, MD, United States, ⁶Lou Ruvo Center for Brain Health, Cleveland Clinic, Las Vegas, NV, United States, ⁷Radiology, Johns Hopkins Hospital, Baltimore, MD, United States

The olfactory cortex is difficult to image with conventional EPI-fMRI due to susceptibility artifacts especially at 7T. T2-prepared (T2prep) fMRI is an alternative method to reduce such artifacts. Here, we show that T2prep-fMRI offers superior temporal signal-to-noise ratio in the olfactory cortex over EPI-fMRI at 7T. The signal characteristics detected using T2prep-fMRI during short (6s) and long (60s) olfactory stimulation were consistent with literature. During the long stimulus, fMRI signals in the olfactory cortex returned to baseline in 5-10s, and activation of secondary olfactory regions (insular, orbitofrontal) were observed, which can be attributed to habituation effects in the olfactory system.

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