Abstract #3939

Inter-site repeatability of motor-visual task fMRI responses at 7 Tesla

Ian D Driver¹, Olivier Mougin², William T Clarke³, Catarina Rua⁴, Andrew T Morgan⁵, Adrian Carpenter⁴, Keith Muir⁵, David Porter⁵, Christopher T Rodgers⁴, Stuart Clare³, Susan T Francis², Richard Bowtell², and Richard G Wise¹

¹Cardiff University Brain Research Imaging Centre, School of Psychology, Cardiff University, Cardiff, United Kingdom, ²Sir Peter Mansfield Imaging Centre, School of Physics and Astronomy, University of Nottingham, Nottingham, United Kingdom, ³Wellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom, ⁴Wolfson Brain Imaging Centre, Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom, ⁵Imaging Centre of Excellence, University of Glasgow, Glasgow, United Kingdom

This work studies cross-site variability in 7 Tesla task fMRI measurements, collected as part of a “travelling heads” study. Participants were scanned at the five human UK 7 Tesla MRI sites, and results are presented from four of these sites. A motor-visual task was performed at each site with acquisitions matched as closely as possible. Despite some apparent differences in tSNR , we demonstrate that it is possible to achieve good agreement across sites. The %BOLD coefficient of variation of 0.1-0.2 across sites was similar to the within-site ranges. This work sets the foundation for multi-site 7 Tesla clinical trials.

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