2D-EPI Multiband and 3D-EPI are commonly used approaches to acquiring high-resolution fMRI scans while maintaining reasonable scan times. In this work, the relative merit of these methods was investigated with respect to acceleration factor, coverage, physiological noise correction, and smoothing kernel. Both methods performed equivalently in term of activation t-scores and temporal SNR, regardless of the coverage or acceleration when no smoothing was applied. However, 2D MB benefited more from smoothing than 3D. Our hypothesis was that this was due to a higher degree of spatial correlation in the noise for the 3D acquisition and was confirmed by additional tests.