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Abstract #3941

An Optimized Processing Procedure for Fetal Resting State Imaging

Matteo Canini1, Paolo Cavoretto2, Veronica Giorgione2, Antonella Iadanza1, Silvia Pontesilli1, Roberta Scotti1, Massimo Candiani2, Paola Scifo3, Andrea Falini1, Pasquale Anthony Della Rosa1, and Cristina Baldoli1

1Department of Neuroradiology, San Raffaele Scientific Institute, Milan, Italy, 2Department of Gynecology, San Raffaele Scientific Institute, Milan, Italy, 3Department of Nuclear Medicine, San Raffaele Scientific Institute, Milan, Italy

Human fetal brain development is marked by the rapid growth of connections between brain structures during the last trimester of pregnancy. Crucially, data processing of fetal rs-functional scans (rs-fMRI) results largely affected by high degrees of movement, which impose severe constraints on interpretation of functional activation patterns leading to potentially biased results. In this work we present a standardized yet flexible preprocessing and normalization procedure allowing for data loss minimization (i.e. allowing to preserve the highest amount of volumes while consistently excluding outliers) and thus fostering reliable group-level inferences.

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