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Abstract #3950

Evaluation of simultaneous multi-slice EPI acquisition with an 8-channel coil for resting state functional MRI

Hesamoddin Jahanian1, Samantha Holdsworth2, Thomas Christen3, Michael Moseley3, and Greg Zaharchuk3

1Department of Radiology, University of Washington, Seattle, WA, United States, 2Department of Anatomy and Medical Imaging & Centre for Brain Research, University of Auckland, Auckland, New Zealand, 3Department of Radiology, Stanford University, Stanford, CA, United States

Simultaneous multi-slice (SMS) imaging has shown to be a promising tool for improving the efficiency of resting state fMRI (rs-fMRI). As the multi-slice acceleration factor in SMS increases, so does the temporal resolution, allowing increased sensitivity of rs-fMRI measurements. However, to achieve high multi-slice acceleration factors, SMS typically uses higher channel (>=32) receiver coils that may not be available in many research and clinical settings. In this study, we explored the efficacy of using SMS with a typical 8-channel receiver coil for rs-fMRI. Upon employing the slice orientation that maximizes the coil sensitivity variation along the slice direction, we were able to acquire high temporal resolution (TR=400 ms) rs-fMRI data. Compared with the conventional-EPI acquisition (TR=2000 ms), the proposed SMS-EPI acquisition provided superior sensitivity and test-retest reliability for rs-fMRI.

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