Abstract #3963

Tabletop MR Elastography (MRE): Preliminary Results Towards an Assessment of Frozen Tissue Bank Samples.

Rolf Otto Reiter^1,2, Martina Guidetti¹, Marco Andrea Zampini¹, Shreyan Majumdar¹, Harish Palnitkar¹, Bernd Hamm², Thomas Royston¹, and Dieter Klatt¹

¹Bioengineering, University of Illinois at Chicago, Chicago, IL, United States, ²Radiology, Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany

Tabletop magnetic resonance elastography (MRE) at 0.5 Tesla was recently introduced as a low-cost technique for assessing mechanical properties of small tissue samples. Frozen tissue banks potentially facilitate access to large amounts of specimens. Therefore, we aimed to characterize changes of mechanical properties of fresh ex vivo (native), and frozen and thawed (lysed) porcine muscle, liver and kidney specimens. Frequency dependent mechanical properties at 500, 1000, 1500 and 2000 Hz decreased uniformly after lysis (ratio lysed/native ranging from 0.46 to 0.60). Rheological fitting was more complex and motivates further investigation of the rheological behavior in native and lysed states.

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