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Abstract #3973

Quantitative Effects of Geometric Distortion On Brain Mechanical Property Estimation In Magnetic Resonance Elastography

Grace McIlvain1, Matthew DJ McGarry2, and Curtis L Johnson3

1Biomedical Engineerng, University of Delaware, Newark, DE, United States, 2Thayer School of Engineering, Dartmouth College, Hanover, NH, United States, 3Biomedical Engineering, University of Delaware, Newark, DE, United States

Geometric distortion in MRI arises from magnetic field-inhomogeneity and susceptibility differences at air/tissue/bone interfaces, and this distortion is greater at long readout times used in high-resolution imaging. Distortion may particularly impact magnetic resonance elastography (MRE), which calculates brain mechanical properties by imaging shear wave displacements then solving applying a nonlinear inversion algorithm. In this study, we systematically examine effects of distortion and correction algorithms on MRE data through a series of simulations and in vivo experiments, and find that geometric distortion limits the quantitative accuracy of brain MRE.

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