Geometric distortion in MRI arises from magnetic field-inhomogeneity and susceptibility differences at air/tissue/bone interfaces, and this distortion is greater at long readout times used in high-resolution imaging. Distortion may particularly impact magnetic resonance elastography (MRE), which calculates brain mechanical properties by imaging shear wave displacements then solving applying a nonlinear inversion algorithm. In this study, we systematically examine effects of distortion and correction algorithms on MRE data through a series of simulations and in vivo experiments, and find that geometric distortion limits the quantitative accuracy of brain MRE.
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