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Abstract #3975

Multi-frequency magnetic resonance elastography with spiral readout, respiratory navigator and stroboscopic wave sampling for cardiac stiffness mapping with high spatial and temporal resolution.

Felix Schrank1, Carsten Warmuth1, Lars-Arne Schaafs1, Heiko Tzschätzsch1, Thomas Elgeti1, Jürgen Braun2, and Ingolf Sack1

1Department of Radiology, Charité - Universitätsmedizin Berlin, Berlin, Germany, 2Institute of Medical Informatics, Charité - Universitätsmedizin Berlin, Berlin, Germany

Cardiac magnetic resonance elastography (MRE) promises a quantitative mapping of the mechanical function of the myocardium. However, the implementation of cardiac MRE is challenging due to fast motion, high heterogeneity and temporally varying intrinsic properties of the heart. To overcome these limitations, we introduce a novel cardiac MRE sequence with spiral readout, respiratory navigator and stroboscopic wave sampling. It allows acquiring 100 wave fields with 45ms temporal resolution, 1.6x1.6mm² in-plane resolution at three frequencies within 9 minutes. Preliminary data in 8 healthy volunteers show a substantial variation of myocardial shear-wave velocity from 1.5±0.2m/s during diastole to 2.1±0.2m/s during systole.

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