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Abstract #3976

Correcting portal-venous partial-volume effects in dynamic contrast-enhanced MRI of the liver

Susmita Basak1, David Longbotham1, Ashley Guthrie2, Daniel Wilson2, Raj Prasad2, and Steven Sourbron1

1Biomedical Imaging Science Department, University of Leeds, Leeds, United Kingdom, 2Leeds Teaching Hospitals NHS Trust, St James University Hospital, Leeds, United Kingdom

We investigated the effect of partial-volume corrections on the liver perfusion and function measured from DCE-MRI data using dual input two compartment uptake model. Following the convection principle in the human body, partial-volume error for hepatic portal vein is determined by taking the ratio of time integrals of venous and arterial input function. We found moderate correlation between the corrected and uncorrected venous plasma flow and a poor correlation between corrected and uncorrected extracellular volume and uptake rate. This indicates that partial-volume effect is significant and should be corrected for in the determination of perfusion and liver function.

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